Lately, it seems as if there’s no hotter or more passionately debated topic in the clinical research enterprise than how artificial intelligence (AI) is—depending on who you’re talking to—tweaking, upending, reinventing, ruining, energizing, saving, or stymieing the people and processes integral to the safe and efficient conduct of clinical trials. Contributors to the June issue of Clinical Researcher look into—and then beyond—the concepts and challenges now at play in AI to consider its practical implications in real-world research settings for the professionals who are tasked with translating the technology’s current promises into tomorrow’s progress.